GenAge entry for FGFR1 (Homo sapiens)
Gene name (HAGRID: 169)
- HGNC symbol
- FGFR1
- Aliases
- H2; H3; H4; H5; CEK; FLG; BFGFR; N-SAM; CD331; FLT2; KAL2
- Common name
- fibroblast growth factor receptor 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
FGFR1 is the receptor of the fibroblast growth factor. Mice with an attenuation of FGFR1 signalling develop diabetes with age and exhibit a decreased number of beta-cells [777]. Lower levels of FGFR1 in mice have also been related to craniofacial defects [778]. Mutations in the human FGFR1 gene have been associated with Pfeiffer [780] and Kallmann syndromes [779]. While FGFR1 could play a role in some age-related diseases, such as diabetes, its involvement in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 8p12
- Location
- 38,411,138 bp to 38,468,834 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001501; skeletal system development
GO:0001525; angiogenesis
GO:0001657; ureteric bud development
GO:0001701; in utero embryonic development
GO:0001759; organ induction
GO:0001764; neuron migration
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002062; chondrocyte differentiation
GO:0006351; transcription, DNA-templated
And 47 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016021; integral component of membrane
GO:0031410; cytoplasmic vesicle
GO:0043235; receptor complex
Function: GO:0004713; protein tyrosine kinase activity
GO:0005007; fibroblast growth factor-activated receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008201; heparin binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0017134; fibroblast growth factor binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
And 2 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- STAT3, CREBBP, HSP90AA1, FGFR1, PIK3R1, JAK2, CTNNB1, FGF23
- STRING interaction network
Retrieve sequences for FGFR1
Homologs in model organisms
- Caenorhabditis elegans
- egl-15
- Danio rerio
- fgfr1b
- Danio rerio
- fgfr1a
- Danio rerio
- fgfr1bl
- Drosophila melanogaster
- htl
- Drosophila melanogaster
- btl
- Mus musculus
- Fgfr1
- Rattus norvegicus
- Fgfr1
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_000604
- CDS Accession
- NP_000595
- OMIM
- 136350
- HPRD
- 00634
- Ensembl
- FGFR1
- UniProt/Swiss-Prot
- FGFR1_HUMAN
- GeneCards
- FGFR1
- Entrez Gene
- 2260
- GenAtlas
- FGFR1
- Internet
- Search Google