GenAge entry for FGF21 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 293)
- HGNC symbol
- FGF21
- Aliases
- Common name
- fibroblast growth factor 21
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
FGF21 is a pro-longevity hormone released by the liver that regulates glucose uptake in adipocytes. Transgenic overexpression of Fgf21 in hepatocytes increases average and maximum lifespan by 36% and 16%, respectively [3252]. Studies suggest that methionine restriction can reverse the negative effects of ageing on body mass, adiposity, and insulin resistance through an FGF21 mechanism [3602]. Given these results and its role in metabolism, FGF21 may play a role in metabolic aspects of ageing. Additionally, FGF21 expression in the thymus declines with age. FGF21 overexpression in mice protects against thymic involution, increases perithymic brown adipose tissue and elevates thymic T-cell export. Loss of FGF21 in middle aged mice accelerates thymic ageing. Thus, FGF21 may integrate the metabolic and immune systems [4359]. In humans, FGF21 resistance has been associated with Type 2 diabetes and it has been shown that FGF21 treatment can alleviate several age-related disorders. Overall, FGF21 resistance might jeopardise human healthspan and accelerate the ageing process [4510].
Cytogenetic information
- Cytogenetic band
- 19q13.33
- Location
- 48,756,087 bp to 48,758,325 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0010898; positive regulation of triglyceride catabolic process
GO:0010988; regulation of low-density lipoprotein particle clearance
GO:0014823; response to activity
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031667; response to nutrient levels
GO:0035690; cellular response to drug
GO:0045716; positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326; positive regulation of glucose import
And 10 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005623; cell
Function: GO:0005104; fibroblast growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
Protein interactions and network
No interactions in records.
Retrieve sequences for FGF21
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Fgf21
- CellAge
- This gene is present as FGF21
Selected references
External links
- EPD
- ORF Accession
- NM_019113
- CDS Accession
- NP_061986
- OMIM
- 609436
- HPRD
- 09447
- Ensembl
- FGF21
- UniProt/Swiss-Prot
- FGF21_HUMAN
- GeneCards
- FGF21
- Entrez Gene
- 26291
- GenAtlas
- FGF21
- Internet
- Search Google