GenAge entry for CLOCK (Homo sapiens)

Gene name (HAGRID: 252)

HGNC symbol
CLOCK 
Aliases
KIAA0334; KAT13D; bHLHe8 
Common name
clock circadian regulator 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

CLOCK forms a heterodimer with ARNTL, which activates circadian rhythm-associated genes. Mice deficient in ARNTL have an impaired circadian behavior, reduced lifespan, and display symptoms of premature ageing associated in some tissues with increased levels of reactive oxygen species [1841][2134]. CLOCK mutant mice do not display predisposition to tumour formation. When challenged with low-dose irradiation, however, they appear to accelerate their ageing program and develop a phenotype reminiscent of ARNTL-deficient mice [1842]. ARNTL and CLOCK also appear to be involved in the response to genotoxic stress [1868]. Overall, CLOCK might play some role in mammalian ageing.

Cytogenetic information

Cytogenetic band
4q12
Location
55,427,901 bp to 55,546,909 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000077; DNA damage checkpoint
GO:0006355; regulation of transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0007165; signal transduction
GO:0007283; spermatogenesis
GO:0007623; circadian rhythm
GO:0009648; photoperiodism
GO:0016573; histone acetylation
GO:0032922; circadian regulation of gene expression
GO:0042634; regulation of hair cycle
And 12 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005694; chromosome
GO:0033391; chromatoid body
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001046; core promoter sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004402; histone acetyltransferase activity
GO:0005515; protein binding
GO:0031490; chromatin DNA binding
GO:0043565; sequence-specific DNA binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, EP300, SIRT1, PPP1CA, CSNK1E, ARNTL
STRING interaction network
Protein-Protein network diagram for CLOCK

Retrieve sequences for CLOCK

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
clocka
Danio rerio
clockb
Drosophila melanogaster
Clk
Mus musculus
Clock
Rattus norvegicus
Clock

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Clock
LongevityMap
  • This gene is present as CLOCK

Selected references

External links

EPD
ORF Accession
NM_004898
CDS Accession
NP_004889
OMIM
601851
HPRD
03508
Ensembl
CLOCK
UniProt/Swiss-Prot
CLOCK_HUMAN
GeneCards
CLOCK
Entrez Gene
9575
UniGene
436975
GenAtlas
CLOCK
Internet
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