GenAge entry for ARNTL (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 251)

HGNC symbol
ARNTL 
Aliases
MOP3; JAP3; BMAL1; PASD3; bHLHe5 
Common name
aryl hydrocarbon receptor nuclear translocator-like 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

ARNTL forms a heterodimer with CLOCK, which activates circadian rhythm-associated genes. Mice deficient in ARNTL have an impaired circadian behavior, reduced lifespan, and display symptoms of premature ageing associated in some tissues with increased levels of reactive oxygen species [1841]. BMAL1 deficient mice also have an increased activity of mTORC1, and treatment with rapamycin rescues their median lifespan by ~50% and maximum lifespan by ~25% [3627].

Cytogenetic information

Cytogenetic band
11p15
Location
13,277,727 bp to 13,387,265 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000060; protein import into nucleus, translocation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0007283; spermatogenesis
GO:0007623; circadian rhythm
GO:0032007; negative regulation of TOR signaling
GO:0032922; circadian regulation of gene expression
GO:0042176; regulation of protein catabolic process
GO:0042634; regulation of hair cycle
GO:0042753; positive regulation of circadian rhythm
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
And 16 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0016605; PML body
GO:0033391; chromatoid body
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001046; core promoter sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0005515; protein binding
GO:0017162; aryl hydrocarbon receptor binding
GO:0043425; bHLH transcription factor binding
GO:0043565; sequence-specific DNA binding
GO:0046982; protein heterodimerization activity
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, HIF1A, HSP90AA1, EP300, SIRT1, PPP1CA, CSNK1E, CLOCK
STRING interaction network
Protein-Protein network diagram for ARNTL

Retrieve sequences for ARNTL

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
arntl1b
Danio rerio
arntl1a
Drosophila melanogaster
cyc
Mus musculus
Arntl
Rattus norvegicus
Arntl

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Arntl
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Arntl
LongevityMap
  • This gene is present as ARNTL

Selected references

External links

EPD
ORF Accession
NM_001178
CDS Accession
NP_001169
OMIM
602550
HPRD
03973
Ensembl
ARNTL
UniProt/Swiss-Prot
BMAL1_HUMAN
GeneCards
ARNTL
Entrez Gene
406
UniGene
65734
GenAtlas
ARNTL
Internet
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