GenAge entry for TP63 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 234)

HGNC symbol
TP63 
Aliases
p51; SHFM4; EEC3; p63; p73L; OFC8; KET; p73H; NBP; p53CP; TP73L; TP53L; TP53CP 
Common name
tumor protein p63 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

TP63 is a homologue of TP53 that plays a role in development and oncogenesis by regulating proliferation and differentiation [1487]. This gene encodes several isoforms whose expression differs between tissues. TP63-null mice have major developmental defects [1489] and stem cells lacking p63 undergo a premature proliferative rundown in stratified epithelia [3669]. Heterozygous TP63 mice have a reduced lifespan (over 20% shorter than controls) and exhibit signs of premature ageing [1491]. Mutations in TP63 in humans have been associated with several disorders, including EEC which is characterized by ectrodactyly, ectodermal dysplasia, and facial clefts [1488]. Corneal dystrophy and premature menopause have also been associated with a mutation in TP63 [1942].

Cytogenetic information

Cytogenetic band
3q28
Location
189,631,427 bp to 189,897,279 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001302; replicative cell aging
GO:0001501; skeletal system development
GO:0001736; establishment of planar polarity
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002064; epithelial cell development
GO:0006338; chromatin remodeling
GO:0006366; transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219; Notch signaling pathway
And 45 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005791; rough endoplasmic reticulum
GO:0005829; cytosol
GO:0030425; dendrite
Function: GO:0000989; transcription factor activity, transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0002039; p53 binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0042802; identical protein binding
GO:0043565; sequence-specific DNA binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, BRCA1, VCP, NFKB1, UBE2I, CEBPB, STK11, EP300, PML, FAS, A2M, RELA, EEF1A1, MDM2, SUMO1, CDKN2A, TP63, CDKN1A, IKBKB
STRING interaction network
Protein-Protein network diagram for TP63

Retrieve sequences for TP63

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
tp63
Mus musculus
Trp63
Rattus norvegicus
Tp63

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Trp63
CellAge
  • This gene is present as TP63

Selected references

External links

EPD
ORF Accession
NM_003722
CDS Accession
NP_003713
OMIM
603273
HPRD
04469
Ensembl
TP63
UniProt/Swiss-Prot
P63_HUMAN
GeneCards
TP63
Entrez Gene
8626
UniGene
137569
GenAtlas
TP63
Internet
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