GenAge entry for SUMO1 (Homo sapiens)

Gene name (HAGRID: 211)

HGNC symbol
SUMO1 
Aliases
PIC1; GMP1; SMT3C; SUMO-1; SMT3H3; OFC10; UBL1 
Common name
small ubiquitin-like modifier 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

SUMO1 is a small protein that interacts with several partners and hence is related to many processes, including DNA repair and signal transduction. It may be related to WRN [903]. There is no evidence associating SUMO1 with ageing, though because of its many functions it is possible that SUMO1 has some impact on human ageing.

Cytogenetic information

Cytogenetic band
2q33
Location
202,206,180 bp to 202,238,599 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006281; DNA repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0030578; PML body organization
GO:0031334; positive regulation of protein complex assembly
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880; regulation of protein localization
GO:0034605; cellular response to heat
GO:0043392; negative regulation of DNA binding
GO:0043433; negative regulation of sequence-specific DNA binding transcription factor activity
And 12 more GO terms
Cellular component: GO:0000792; heterochromatin
GO:0001650; fibrillar center
GO:0001741; XY body
GO:0005634; nucleus
GO:0005643; nuclear pore
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0008076; voltage-gated potassium channel complex
GO:0016604; nuclear body
And 7 more GO terms
Function: GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0015459; potassium channel regulator activity
GO:0031386; protein tag
GO:0031625; ubiquitin protein ligase binding
GO:0044325; ion channel binding
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, WRN, BRCA1, CREBBP, BLM, VCP, NR3C1, TOP2B, RAD51, UBE2I, PML, FAS, FOXM1, RAD52, JUN, ATF2, BUB1B, PTGS2, MDM2, SUMO1, MTOR, TP63, NCOR2, TP73, NFE2L2
STRING interaction network
Protein-Protein network diagram for SUMO1

Retrieve sequences for SUMO1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
smo-1
Danio rerio
sumo1
Mus musculus
Sumo1
Rattus norvegicus
Sumo1
Saccharomyces cerevisiae
SMT3
Schizosaccharomyces pombe
pmt3

Selected references

External links

EPD
HS_UBL1
ORF Accession
NM_003352
CDS Accession
NP_003343
OMIM
601912
HPRD
03554
Ensembl
SUMO1
UniProt/Swiss-Prot
SUMO1_HUMAN
GeneCards
SUMO1
Entrez Gene
7341
UniGene
81424
GenAtlas
SUMO1
Internet
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