GenAge entry for COQ7 (Homo sapiens)

Gene name (HAGRID: 132)

HGNC symbol
COQ7 
Aliases
CLK-1; CAT5 
Common name
coenzyme Q7 homolog, ubiquinone (yeast) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

COQ7's functions are unclear, but it may be a metabolic regulator involved in several metabolic pathways such as the biosynthesis of ubiquinone, in turn an antioxidant involved in mitochondrial respiration [675]. In roundworms, the COQ7 homologue clk-1 affects developmental timing and lifespan [946]. Food restriction does not further increase the lifespan of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes [1820]. Knocking out COQ7 in mice results in developmental arrest at midgestation [1613]. Heterozygous mice live about 15 to 30% longer than controls, though it is unclear whether ageing is delayed [1612]. They also exhibit surprisingly high levels of oxidative damage and early mitochondrial dysfunction [2087]. Although it is possible for COQ7 to play a role in human ageing, further research is needed to investigate this possibility.

Cytogenetic information

Cytogenetic band
16p12.3
Location
19,067,595 bp to 19,080,095 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006744; ubiquinone biosynthetic process
GO:0055114; oxidation-reduction process
Cellular component: GO:0005634; nucleus
GO:0005743; mitochondrial inner membrane
Function: GO:0004497; monooxygenase activity
GO:0005515; protein binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
COQ7
STRING interaction network
Protein-Protein network diagram for COQ7

Retrieve sequences for COQ7

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
clk-1
Danio rerio
coq7
Drosophila melanogaster
COQ7
Mus musculus
Coq7
Rattus norvegicus
Coq7
Saccharomyces cerevisiae
CAT5
Schizosaccharomyces pombe
coq7

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as clk-1
  • A homolog of this gene for Mus musculus is present as Coq7
  • A homolog of this gene for Saccharomyces cerevisiae is present as CAT5
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as clk-1
LongevityMap
  • This gene is present as COQ7

Selected references

External links

EPD
ORF Accession
NM_016138
CDS Accession
NP_057222
OMIM
601683
HPRD
03401
Ensembl
COQ7
UniProt/Swiss-Prot
COQ7_HUMAN
GeneCards
COQ7
Entrez Gene
10229
UniGene
157113
GenAtlas
COQ7
Internet
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