GenAge entry for TGFB1 (Homo sapiens)

Gene name (HAGRID: 91)

HGNC symbol
TGFB1 
Aliases
CED; TGFbeta; TGFB; DPD1 
Common name
transforming growth factor, beta 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

TGFB1 is an important growth factor in development and differentiation. Some evidence suggests TGFB1 is involved in the response to oxidative stress [137]. In roundworms, it has been argued that a TGFB signalling pathway acts downstream of other signals to repress body size and lifespan [1703]. Mutations in TGFB1 have been linked to several pathologies in humans [500], and a polymorphism in this gene has been associated with human longevity [1254]. Nonetheless, it is unclear if/how TGFB1 influences human ageing.

Cytogenetic information

Cytogenetic band
19q13.1
Location
41,330,531 bp to 41,353,933 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000060; protein import into nucleus, translocation
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001570; vasculogenesis
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0001837; epithelial to mesenchymal transition
GO:0001843; neural tube closure
GO:0001933; negative regulation of protein phosphorylation
GO:0001934; positive regulation of protein phosphorylation
GO:0002028; regulation of sodium ion transport
And 170 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005796; Golgi lumen
GO:0005886; plasma membrane
GO:0005902; microvillus
GO:0009986; cell surface
GO:0030424; axon
GO:0031012; extracellular matrix
And 4 more GO terms
Function: GO:0001948; glycoprotein binding
GO:0003823; antigen binding
GO:0005114; type II transforming growth factor beta receptor binding
GO:0005125; cytokine activity
GO:0005160; transforming growth factor beta receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0019899; enzyme binding
GO:0034713; type I transforming growth factor beta receptor binding
GO:0034714; type III transforming growth factor beta receptor binding
GO:0042803; protein homodimerization activity
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
APP
STRING interaction network
Protein-Protein network diagram for TGFB1

Retrieve sequences for TGFB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
tgfb1b
Danio rerio
tgfb1a
Drosophila melanogaster
daw
Mus musculus
Tgfb1
Rattus norvegicus
Tgfb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as daw
LongevityMap
  • This gene is present as TGFB1

Selected references

External links

EPD
ORF Accession
NM_000660
CDS Accession
NP_000651
OMIM
190180
HPRD
01821
Ensembl
TGFB1
UniProt/Swiss-Prot
TGFB1_HUMAN
GeneCards
TGFB1
Entrez Gene
7040
UniGene
645227
GenAtlas
TGFB1
Internet
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