GenAge entry for NFKB1 (Homo sapiens)

Gene name (HAGRID: 82)

HGNC symbol
NFKB1 
Aliases
KBF1; p105; NFKB-p50; p50; NF-kappaB; NFkappaB; NF-kB1 
Common name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

NFKB1 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB1 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261]. In nfkb1-/- mice, both median and maximum lifespan are reduced (median is ~33% lower). The reduction in lifespan is also acompanied by multiple signs of premature ageing (hair loss or early greying, scruffy fur and cachexia, skin inflammation and delayed wound healing, thinning of the epidermis, lost neuromuscular coordination, premature body mass loss and loss of fat from inguinal, epididymal and mesenteric depots) [3544].

Cytogenetic information

Cytogenetic band
4q24
Location
102,501,329 bp to 102,617,302 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006366; transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0010629; negative regulation of gene expression
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0010884; positive regulation of lipid storage
GO:0010956; negative regulation of calcidiol 1-monooxygenase activity
GO:0010957; negative regulation of vitamin D biosynthetic process
And 27 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0033256; I-kappaB/NF-kappaB complex
Function: GO:0000975; regulatory region DNA binding
GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227; transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0042802; identical protein binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TXN, E2F1, NFKB2, STAT3, STAT5A, HDAC3, NCOR1, PARP1, VCP, NR3C1, NFKB1, CEBPB, EP300, PML, GSK3B, RELA, HDAC1, SP1, HMGB1, TFAP2A, HDAC2, NFKBIA, CLU, CTNNB1, TP63, PPARGC1A, PPARG, TP53BP1, NCOR2, IKBKB
STRING interaction network
Protein-Protein network diagram for NFKB1

Retrieve sequences for NFKB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nfkb1
Drosophila melanogaster
Rel
Mus musculus
Nfkb1
Rattus norvegicus
Nfkb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Nfkb1
LongevityMap
  • This gene is present as NFKB1

Selected references

External links

EPD
ORF Accession
NM_003998
CDS Accession
NP_003989
OMIM
164011
HPRD
01238
Ensembl
NFKB1
UniProt/Swiss-Prot
NFKB1_HUMAN
GeneCards
NFKB1
Entrez Gene
4790
UniGene
654408
GenAtlas
NFKB1
Internet
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