GenAge entry for UBB (Homo sapiens)

Gene name (HAGRID: 66)

HGNC symbol
UBB 
Aliases
MGC8385; FLJ25987 
Common name
ubiquitin B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

UBB is involved in the regulation of chromatin structure and stress response, as well as in the degradation of cellular proteins [439]. In lower life forms, such as invertebrates, stress-response proteins similar to UBB have been associated with ageing. UBB has also been associated with neurodegenerative diseases [436]. Although unproven, a role for UBB in ageing and/or age-related diseases is possible.

Cytogenetic information

Cytogenetic band
17p12-p11.
Location
16,380,797 bp to 16,382,745 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000209; protein polyubiquitination
GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0002755; MyD88-dependent toll-like receptor signaling pathway
GO:0002756; MyD88-independent toll-like receptor signaling pathway
GO:0005978; glycogen biosynthetic process
And 66 more GO terms
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0010008; endosome membrane
GO:0030666; endocytic vesicle membrane
GO:0043005; neuron projection
GO:0043025; neuronal cell body
GO:0070062; extracellular exosome
And 1 more GO terms
Function: GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, VCP, APP, CDKN1A, SPRTN
STRING interaction network
Protein-Protein network diagram for UBB

Retrieve sequences for UBB

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ubq-1
Saccharomyces cerevisiae
UBI4

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as UBI4

Selected references

External links

EPD
HS_UBB
ORF Accession
NM_018955
CDS Accession
NP_061828
OMIM
191339
HPRD
06771
Ensembl
UBB
UniProt/Swiss-Prot
UBIQ_HUMAN
GeneCards
UBB
Entrez Gene
7314
UniGene
356190
GenAtlas
UBB
Internet
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