GenAge entry for PEX5 (Homo sapiens)

Gene name (HAGRID: 58)

HGNC symbol
PEX5 
Aliases
PTS1R; PXR1 
Common name
peroxisomal biogenesis factor 5 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

A peroxisome receptor, PEX5 has been associated with genes and pathways previously related to ageing, such as ATM [994]. An involvement in cellular senescence has also been suggested [402]. Nonetheless, a direct role of PEX5 in human ageing has not been demonstrated.

Cytogenetic information

Cytogenetic band
12p13.31
Location
7,190,362 bp to 7,211,483 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0016558; protein import into peroxisome matrix
GO:0016560; protein import into peroxisome matrix, docking
GO:0045046; protein import into peroxisome membrane
GO:1901094; negative regulation of protein homotetramerization
Cellular component: GO:0005737; cytoplasm
GO:0005777; peroxisome
GO:0005778; peroxisomal membrane
GO:0016020; membrane
GO:0043234; protein complex
Function: GO:0000268; peroxisome targeting sequence binding
GO:0005052; peroxisome matrix targeting signal-1 binding
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0031267; small GTPase binding
GO:0047485; protein N-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ATM, BRCA1, CAT, SIRT3, SQSTM1
STRING interaction network
Protein-Protein network diagram for PEX5

Retrieve sequences for PEX5

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
prx-5
Danio rerio
pex5
Drosophila melanogaster
Pex5
Mus musculus
Pex5
Rattus norvegicus
LOC103690024
Rattus norvegicus
Pex5
Saccharomyces cerevisiae
PEX5

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as prx-5
  • A homolog of this gene for Saccharomyces cerevisiae is present as PEX5

Selected references

External links

EPD
ORF Accession
NM_000319
CDS Accession
NP_000310
OMIM
600414
HPRD
02684
Ensembl
PEX5
UniProt/Swiss-Prot
PEX5_HUMAN
GeneCards
PEX5
Entrez Gene
5830
UniGene
567327
GenAtlas
PEX5
Internet
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