GenAge entry for NGF (Homo sapiens)

Gene name (HAGRID: 31)

HGNC symbol
NGF 
Aliases
NGFB 
Common name
nerve growth factor (beta polypeptide) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

A neurotrophin important for the development and maintenance of the central nervous system, NGF stimulates division and differentiation [319]. It has been linked with neurodegenerative age-related pathology [318].

Cytogenetic information

Cytogenetic band
1p13.1
Location
115,285,916 bp to 115,338,236 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000186; activation of MAPKK activity
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007018; microtubule-based movement
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267; cell-cell signaling
GO:0008625; extrinsic apoptotic signaling pathway via death domain receptors
GO:0010628; positive regulation of gene expression
GO:0032455; nerve growth factor processing
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
And 9 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005768; endosome
GO:0005796; Golgi lumen
Function: GO:0005163; nerve growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008191; metalloendopeptidase inhibitor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NGFR, A2M
STRING interaction network
Protein-Protein network diagram for NGF

Retrieve sequences for NGF

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ngfb
Danio rerio
ngfa
Mus musculus
Ngf
Rattus norvegicus
Ngf

Selected references

External links

EPD
ORF Accession
NM_002506
CDS Accession
NP_002497
OMIM
162030
HPRD
08874
Ensembl
NGF
UniProt/Swiss-Prot
NGF_HUMAN
GeneCards
NGF
Entrez Gene
4803
UniGene
2561
GenAtlas
NGF
Internet
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