GenAge entry for HSF1 (Homo sapiens)

Gene name (HAGRID: 125)

HGNC symbol: HSF1
Aliases: HSTF1
Common name: heat shock transcription factor 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: A transcription factor that is activated upon heat shock, HSF1 regulates heat-shock response genes and has been associated with ageing in lower life forms. In roundworms, reducing the activity of a HSF1 homologue appears to accelerate ageing while overexpressing it extends lifespan [626]. In mammals, stress-response appears to diminish with age and it has been reported that HSF1 in aged rats exhibits a decreased ability to bind DNA [458]. Disruption of HSF1 in mice results in multiple defects, including increased prenatal lethality, growth retardation, female infertility, and increased susceptibility to stress [634]. Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant [3545]. Although HSF1 has not been directly linked to human ageing, it is possible HSF1 plays some role in human ageing.

Cytogenetic information

Cytogenetic band: 8q24.3
Location: 144,291,588 bp to 144,314,722 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001892; embryonic placenta development
GO:0006468; protein phosphorylation
GO:0006952; defense response
GO:0007143; female meiotic division
GO:0007283; spermatogenesis
GO:0007584; response to nutrient
GO:0008285; negative regulation of cell proliferation
GO:0009299; mRNA transcription
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
GO:0014823; response to activity
GO:0032720; negative regulation of tumor necrosis factor production
GO:0033574; response to testosterone
GO:0034605; cellular response to heat
GO:0035865; cellular response to potassium ion
GO:0040018; positive regulation of multicellular organism growth
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051260; protein homooligomerization
GO:0060136; embryonic process involved in female pregnancy
GO:0061408; positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0070207; protein homotrimerization
GO:0070301; cellular response to hydrogen peroxide
GO:0071222; cellular response to lipopolysaccharide
GO:0071276; cellular response to cadmium ion
GO:0071392; cellular response to estradiol stimulus
GO:0071478; cellular response to radiation
GO:0090084; negative regulation of inclusion body assembly
GO:0090261; positive regulation of inclusion body assembly
GO:1900034; regulation of cellular response to heat
GO:1900365; positive regulation of mRNA polyadenylation
GO:1901215; negative regulation of neuron death
GO:1902512; positive regulation of apoptotic DNA fragmentation
GO:1904385; cellular response to angiotensin
GO:1904528; positive regulation of microtubule binding
GO:1904843; cellular response to nitroglycerin
GO:1904845; cellular response to L-glutamine
GO:1990910; response to hypobaric hypoxia
GO:1990911; response to psychosocial stress

Cellular component:

GO:0000791; euchromatin
GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016605; PML body
GO:0043234; protein complex
GO:0045120; pronucleus
GO:0097165; nuclear stress granule

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001162; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0031072; heat shock protein binding
GO:0042802; identical protein binding
GO:0043621; protein self-association
GO:0097677; STAT family protein binding
GO:0098847; sequence-specific single stranded DNA binding
GO:1990841; promoter-specific chromatin binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CREBBP, HSP90AA1, UBE2I, CEBPB, PRKDC, XRCC5, XRCC6, HSF1, SIRT1, HDAC1, HSPA1A, MAPK8, TBP, HSPA8, HDAC2, STUB1
STRING interaction network

Retrieve sequences for HSF1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: hsf-1
Danio rerio: hsf1
Drosophila melanogaster: Hsf
Mus musculus: Hsf1
Rattus norvegicus: Hsf1
Saccharomyces cerevisiae: HSF1
Schizosaccharomyces pombe: hsf1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as hsf-1

GenDR gene manipulations

A homolog of this gene for Caenorhabditis elegans is present as hsf-1

CellAge

This gene is present as HSF1