GenAge entry for GTF2H2 (Homo sapiens)

Gene name (HAGRID: 111)

HGNC symbol: GTF2H2
Aliases: BTF2; TFIIH; BTF2P44; T-BTF2P44; p44
Common name: general transcription factor IIH, polypeptide 2, 44kDa

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: GTF2H2 is a component of the core TFIIH basal transcription factor that is involved in DNA repair and transcription [954]. The association of TFIIH with some ageing-related genes, such as ERCC2 [955], suggests GTF2H2 may also play a role in ageing, though further studies are needed to investigate this hypothesis.

Cytogenetic information

Cytogenetic band: 5q13.2
Location: 70,415,374 bp to 70,447,906 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0002031; G-protein coupled receptor internalization
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
GO:0006363; termination of RNA polymerase I transcription
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006370; 7-methylguanosine mRNA capping
GO:0006412; translation
GO:0006468; protein phosphorylation
GO:0009411; response to UV
GO:0033683; nucleotide-excision repair, DNA incision
GO:0070911; global genome nucleotide-excision repair

Cellular component:

GO:0000438; core TFIIH complex portion of holo TFIIH complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005669; transcription factor TFIID complex
GO:0005675; holo TFIIH complex

Function:

GO:0003676; nucleic acid binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004672; protein kinase activity
GO:0005515; protein binding
GO:0008094; DNA-dependent ATPase activity
GO:0008135; translation factor activity, RNA binding
GO:0008270; zinc ion binding
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0047485; protein N-terminus binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: ERCC2, ERCC8, ERCC3, AR, CDK7
STRING interaction network

Retrieve sequences for GTF2H2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: T16H12.4
Danio rerio: gtf2h2
Drosophila melanogaster: Ssl1
Mus musculus: Gtf2h2
Rattus norvegicus: Gtf2h2
Saccharomyces cerevisiae: SSL1