GenAge entry for GHRHR (Homo sapiens)

Gene name (HAGRID: 222)

HGNC symbol: GHRHR
Aliases
Common name: growth hormone releasing hormone receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: GHRHR is mostly expressed in the pituitary and functions as the receptor for GHRH. Different splice variants appear to exist. Knock-out mice without GHRHR, called little mice, live about 25% longer than controls [5], but it is unclear whether their ageing process is delayed. Mutations in the human GHRHR gene have been associated with growth deficiency and dwarfism [1751], though there is no indication that these patients live longer. GHRHR might play a role in human ageing through the GH1/IGF1 axis.

Cytogenetic information

Cytogenetic band: 7p14
Location: 30,964,021 bp to 30,979,531 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007166; cell surface receptor signaling pathway
GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190; activation of adenylate cyclase activity
GO:0007595; lactation
GO:0008284; positive regulation of cell proliferation
GO:0008340; determination of adult lifespan
GO:0019933; cAMP-mediated signaling
GO:0030104; water homeostasis
GO:0030252; growth hormone secretion
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0033143; regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018; positive regulation of multicellular organism growth
GO:0042445; hormone metabolic process
GO:0043568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627; response to estrogen
GO:0046010; positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0048469; cell maturation
GO:0048609; multicellular organismal reproductive process
GO:0051246; regulation of protein metabolic process
GO:0051384; response to glucocorticoid
GO:0060124; positive regulation of growth hormone secretion
GO:0060133; somatotropin secreting cell development
GO:0071333; cellular response to glucose stimulus

Cellular component:

GO:0005637; nuclear inner membrane
GO:0005640; nuclear outer membrane
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0016021; integral component of membrane
GO:0016363; nuclear matrix
GO:0030141; secretory granule
GO:0042383; sarcolemma

Function:

GO:0004930; G-protein coupled receptor activity
GO:0005515; protein binding
GO:0016520; growth hormone-releasing hormone receptor activity
GO:0017046; peptide hormone binding
GO:0019838; growth factor binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHRH
STRING interaction network

Retrieve sequences for GHRHR

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ghrhrl
Mus musculus: Ghrhr
Rattus norvegicus: Ghrhr

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ghrhr

LongevityMap

This gene is present as GHRHR