GenAge entry for CSNK1E (Homo sapiens)

Gene name (HAGRID: 244)

HGNC symbol: CSNK1E
Aliases: HCKIE; CKIE; CKIepsilon
Common name: casein kinase 1, epsilon

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems

Description

CSNK1E is a member of the serine/threonine protein kinase family. It can phosphorylate a number of proteins, including circadian rhythm proteins, meaning it may be involved in many processes.

The tau mutation in CSNK1E is a semidominant autosomal allele that shortens the length of circadian rhythms in Syrian hamsters [1831]. It also increases metabolic rate [1835]. In these animals, this mutation decreases longevity under normal conditions [1833], but if animals are kept in darkness and under constant temperature lifespan is extended 14-16% [1426], though it is not clear ageing is delayed.

Cytogenetic information

Cytogenetic band: 22q13.1
Location: 38,290,691 bp to 38,318,084 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000086; G2/M transition of mitotic cell cycle
GO:0006281; DNA repair
GO:0006364; rRNA processing
GO:0006468; protein phosphorylation
GO:0006897; endocytosis
GO:0007165; signal transduction
GO:0008360; regulation of cell shape
GO:0016055; Wnt signaling pathway
GO:0018105; peptidyl-serine phosphorylation
GO:0030178; negative regulation of Wnt signaling pathway
GO:0032091; negative regulation of protein binding
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032922; circadian regulation of gene expression
GO:0034613; cellular protein localization
GO:0042752; regulation of circadian rhythm
GO:0048512; circadian behavior
GO:0090263; positive regulation of canonical Wnt signaling pathway
GO:1902004; positive regulation of beta-amyloid formation
GO:1903827; regulation of cellular protein localization
GO:1905426; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
GO:1990090; cellular response to nerve growth factor stimulus
GO:2000052; positive regulation of non-canonical Wnt signaling pathway

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0030426; growth cone
GO:0030529; intracellular ribonucleoprotein complex
GO:0043025; neuronal cell body

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0044822; poly(A) RNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, MYC, APP, PCMT1, MAPK9, PPP1CA, CSNK1E, ARNTL, CLOCK
STRING interaction network

Retrieve sequences for CSNK1E

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: kin-20
Danio rerio: csnk1e
Drosophila melanogaster: dco
Mus musculus: Csnk1e
Rattus norvegicus: Csnk1e
Saccharomyces cerevisiae: HRR25