Mus musculusGenAge entry for Serpine1 (Mus musculus)

Gene information (ID: 1851)

Symbol
Serpine1
Name
serine (or cysteine) peptidase inhibitor, clade E, member 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
The KLOTHO-deficient mice exhibit an accelerated aging phenotype including reduced lifespan, arteriosclerosis, and emphysema. PAI-1 (SERPINE1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan of the mutant mice. Median lifespan of KLOTHO/PAI-1 deficient mice is 2.8-fold and 4.2-fold higher (for PAI-1+/- and PAI-1-/- respectively) than the lifespan of KLOTHO deficient mice. Similar lifespan prolongation was obtained pharmacologically with a PAI-1 antagonist. Both males and females appear to benefit from complete PAI-1 deficiency, whil pai-1+/- deficiency had a smaller effect on females than on males. Maximum lifespan is also increased. The lifespan extension was also accompanied by increased overall vigor and health, the mutant mice exhibiting near-normal weight gain over time and spontaneous physical activity.
Lifespan Effect
Increase
Genetic Manipulation
Deletion in the Klotho mutant background
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SERPINE1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SERPINE1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SERPINE1

    Homologs in other organisms

    Caenorhabditis elegans
    srp-3
    Caenorhabditis elegans
    srp-2
    Caenorhabditis elegans
    srp-1
    Caenorhabditis elegans
    srp-7
    Caenorhabditis elegans
    srp-6
    Caenorhabditis elegans
    srp-8
    Danio rerio
    serpine1
    Drosophila melanogaster
    Spn38F
    Drosophila melanogaster
    Spn28F
    Drosophila melanogaster
    Spn42Dd
    Drosophila melanogaster
    Spn42Da
    Drosophila melanogaster
    Spn28Db
    Drosophila melanogaster
    Spn55B
    Drosophila melanogaster
    Spn42Db
    Drosophila melanogaster
    Spn28Da
    Drosophila melanogaster
    Spn28B
    Drosophila melanogaster
    Spn42Dc
    Drosophila melanogaster
    Spn42De
    Drosophila melanogaster
    nec
    Drosophila melanogaster
    Spn43Aa
    Drosophila melanogaster
    Spn43Ab
    Drosophila melanogaster
    Spn47C
    Homo sapiens
    SERPINE1
    Rattus norvegicus
    Serpine1

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (18787)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar