- Symbol
- Cdk7
- Aliases
- Crk4; Cdkn7; AI323415; AI528512; C230069N13
- Name
- cyclin-dependent kinase 7
- Organism
- Mus musculus (AnAge)
- Observations
- Cdk7 deficiency causes early embryonic lethality. However, ablation of Cdk7 in adult animals resulted in age-related phenotypes, including weight loss, pervasive hair-greying, kyphosis and premature death with <20% of animals living more than one year.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cdk-7
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as CDK7
- Caenorhabditis elegans
- cdk-7
- Danio rerio
- cdk7
- Drosophila melanogaster
- Cdk7
- Homo sapiens
- CDK7
- Rattus norvegicus
- Cdk7
- Saccharomyces cerevisiae
- KIN28
- Schizosaccharomyces pombe
- crk1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (12572)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Cdk7 (Mus musculus)