- Symbol
- ddl-1
- Name
- Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Predicted coiled-coil protein
- Observations
- RNA interference results in lifespan extension.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Inhibition of DDL-1/2 increases longevity and thermotolerance in an hsf-1-dependent manner. RNAi extends lifespan by 12%-24%.
- % change in avg or median lifespan
- Lifespan is 12-24% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- ccdc53
- Drosophila melanogaster
- CG7429
- Homo sapiens
- WASHC3
- Mus musculus
- Washc3
- Rattus norvegicus
- Washc3
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173954)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for ddl-1 (Caenorhabditis elegans)