Drosophila melanogasterGenAge entry for Ilp2 (Drosophila melanogaster)

Gene information (ID: 855)

Symbol
Ilp2
Aliases
CG8167; dilp; Dilp; DILP; Dilp; 2; dilp-2; dILP-2; Dilp-2;
Name
Insulin-related peptide
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
The ablated flies exhibited a significant increase in median and maximum lifespan over that of control flies and an increased resistance to oxidative stress and starvation.The mutants also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold.
% change in max lifespan
Maximum female lifespan is up to 40% higher; Maximum male lifespan is approximately 27% higher.
% change in avg or median lifespan
Median female lifespan is up to 33.5% higher; Median male lifespan is 10.5% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA interference resulted in a 24% to 47% increase in median lifespan compared to controls.
    % change in avg or median lifespan
    Lifespan is 24-47% higher
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as Ilp2

      Homologs in other organisms

      No homologs found

      External links

      FlyBase
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (39150)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar