Drosophila melanogasterGenAge entry for E(z) (Drosophila melanogaster)

Gene information (ID: 844)

Symbol
E(z)
Aliases
CG6502; Dmel\CG6502; E(Z); E(z)1; Ez; EZ; E[z]; l(3)1902;
Name
Enhancer of zeste
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Flies heterozygous for the protein null E(z)63 or the catalytically inactive E(z)731 mutation that were progeny of an out-cross to an Oregon-R (O-R) wild-type strain exhibited a substantially greater median life span than the O-R control (71% and 76%, respectively). When derived from an out-cross to a longer-lived Canton-S (C-S) wild-type strain, the median life span of E(z)63 heterozygotes was 33% longer than the C-S control
% change in max lifespan
Maximum lifespan is approximately 54% higher.
% change in avg or median lifespan
Median lifespan is 76% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SET1
    • A homolog of this gene for Caenorhabditis elegans is present as mes-2
    CellAge
    • A homolog of this gene for Homo sapiens is present as EZH2
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as EZH2

    Homologs in other organisms

    Caenorhabditis elegans
    mes-2
    Danio rerio
    ezh2
    Danio rerio
    ezh1
    Homo sapiens
    EZH2
    Homo sapiens
    EZH1
    Mus musculus
    Ezh2
    Mus musculus
    Ezh1
    Rattus norvegicus
    Ezh2
    Rattus norvegicus
    Ezh1
    Saccharomyces cerevisiae
    SET1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (39203)
    Homologues
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    UniProt
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    Internet
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