- Symbol
- Sirt2
- Aliases
- CG5085; D.mel2; Dmel\CG5085; dSIRT2; SIRT2
- Name
- CG5085-PA
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- NAD(+)-dependent histone deacetylase that silences gene expression
- Observations
- Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%.
- % change in avg or median lifespan
- Average lifespan is 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as HST2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as HST2
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT2
- Danio rerio
- sirt2
- Homo sapiens
- SIRT2
- Mus musculus
- Sirt2
- Rattus norvegicus
- Sirt2
- Saccharomyces cerevisiae
- HST2
- Schizosaccharomyces pombe
- hst2
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (42414)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Sirt2 (Drosophila melanogaster)