Saccharomyces cerevisiaeGenAge entry for ROM2 (Saccharomyces cerevisiae)

Gene information (ID: 554)

Symbol
ROM2
Name
GDP/GTP exchange protein (GEP) for Rho1p and Rho2p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Activator of protein kinase C

Potential relevance to longevity and/or ageing

Observations
Deletion increased mean replicative lifespan by about 30%.
% change in avg or median lifespan
Average replicative lifespan is about 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Replicative lifespan increased by 50% in the alpha strain and 20% in a strain
    % change in avg or median lifespan
    Replicative lifespan is 20-50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      CellAge gene expression
      • A homolog of this gene for Homo sapiens is present as ARHGEF3

      Homologs in other organisms

      Caenorhabditis elegans
      Y105E8A.25
      Caenorhabditis elegans
      rhgf-1
      Danio rerio
      arhgef2
      Danio rerio
      arhgef28
      Danio rerio
      arhgef18b
      Danio rerio
      ARHGEF12 (1 of many)
      Danio rerio
      arhgef3
      Danio rerio
      arhgef11
      Danio rerio
      arhgef1b
      Danio rerio
      si:dkey-91i10.2
      Danio rerio
      arhgef1a
      Danio rerio
      AKAP13 (1 of many)
      Danio rerio
      arhgef18a
      Danio rerio
      net1
      Danio rerio
      arhgef3l
      Danio rerio
      si:ch211-272b8.6
      Danio rerio
      arhgef12b
      Danio rerio
      AKAP13 (1 of many)
      Drosophila melanogaster
      RhoGEF2
      Drosophila melanogaster
      CG10188
      Drosophila melanogaster
      RhoGEF64C
      Homo sapiens
      ARHGEF1
      Homo sapiens
      NET1
      Homo sapiens
      ARHGEF2
      Homo sapiens
      AKAP13
      Homo sapiens
      ARHGEF11
      Homo sapiens
      0
      Homo sapiens
      ARHGEF3
      Homo sapiens
      ARHGEF18
      Homo sapiens
      ARHGEF12
      Homo sapiens
      ARHGEF28
      Homo sapiens
      ARHGEF1
      Mus musculus
      Arhgef11
      Mus musculus
      Arhgef3
      Mus musculus
      Akap13
      Mus musculus
      Arhgef12
      Mus musculus
      Net1
      Mus musculus
      Arhgef2
      Mus musculus
      Arhgef1
      Mus musculus
      Arhgef28
      Mus musculus
      Arhgef18
      Rattus norvegicus
      Net1
      Rattus norvegicus
      Arhgef1
      Rattus norvegicus
      Arhgef2
      Rattus norvegicus
      Arhgef18
      Rattus norvegicus
      Akap13
      Rattus norvegicus
      Arhgef11
      Rattus norvegicus
      Arhgef12
      Rattus norvegicus
      Arhgef3
      Rattus norvegicus
      Arhgef28

      External links

      Saccharomyces Genome Database
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (851086)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar