- Symbol
- Nfkb1
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
- Organism
- Mus musculus (AnAge)
- Observations
- Both mean and maximum lifespan are reduced in nfkb1-/- mice. The reduction in lifespan is also acompanied by multiple signs of premature ageing (hair loss or early greying, scruffy fur and cachexia, skin inflammation and delayed wound healing, thinning of the epidermis, lost neuromuscular coordination, premature body mass loss and loss of fat from inguinal, epididymal and mesenteric depots).
- % change in avg or median lifespan
- Median lifespan is approximately 33% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as NFKB1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as NFKB1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as NFKB1
- Danio rerio
- nfkb1
- Drosophila melanogaster
- Rel
- Homo sapiens
- NFKB1
- Rattus norvegicus
- Nfkb1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (18033)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Nfkb1 (Mus musculus)