- Symbol
- Gdf15
- Name
- growth differentiation factor 15
- Organism
- Mus musculus (AnAge)
- Observations
- Female hNAG-1 mice (mice expressing hNAG-1/hGDF15) have significantly increased mean and median life spans in two transgenic lines. The effect is stronger in mice on high fat diet than on low fat diet. hNAG-1 mice display reduced body and adipose tissue weight, lowered serum IGF-1, insulin and glucose levels, improved insulin sensitivity, and increased oxygen utilization, oxidative metabolism and energy expenditure.
- % change in avg or median lifespan
- Female mean lifespan is up to 43% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as GDF15
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as GDF15
- Caenorhabditis elegans
- unc-129
- Homo sapiens
- GDF15
- Rattus norvegicus
- Gdf15
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (23886)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Gdf15 (Mus musculus)