- Symbol
- Su(var)205
- Aliases
- CBX5; CG8409; dHP-1a; dHP1; Dmel\CG8409; DmHP-1; DmHP1; E
- Name
- Suppressor of variegation 205
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Reducing HP1 levels by half, as in Su(var)2055 heterozygotes, caused a dramatic shortening of life span compared to isogenic controls (p = 2.03-86). Similar results were found with a second allele, Su(var)2052.
- % change in max lifespan
- Maximum lifespan is 55% lower.
- % change in avg or median lifespan
- Average lifespan is 60% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- A moderate overexpression of HP1, caused by basal activity of the hsp70 promoter, significantly extended life span, resulting in a 23% increase in median life span and a 12% increase in maximum life span (p = 6.31-24).
- % change in max lifespan
- Maximum lifespan is 12% higher.
- % change in avg or median lifespan
- Median lifespan is 23% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as CBX5
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as CBX5
- Danio rerio
- cbx5
- Danio rerio
- cbx1b
- Danio rerio
- cbx1a
- Homo sapiens
- CBX5
- Homo sapiens
- CBX1
- Mus musculus
- Cbx1
- Mus musculus
- Cbx5
- Rattus norvegicus
- Cbx1
- Rattus norvegicus
- Cbx5
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (34119)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Su(var)205 (Drosophila melanogaster)