Saccharomyces cerevisiaeGenAge entry for ALG12 (Saccharomyces cerevisiae)

Gene information (ID: 1698)

Symbol
ALG12
Aliases
ECM39
Name
Asparagine-Linked Glycosylation
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of alg12, a target of the unfolded protein response signaling, increases replicative lifespan. This increase is dependant on Ire1p, a functional ER stress sensor protein.
% change in avg or median lifespan
Mean lifespan is 16% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Replicative lifespan increased by 25% in both the alpha strain and the a strain
    % change in avg or median lifespan
    Replicative lifespan is 25% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as ALG12

      Homologs in other organisms

      Caenorhabditis elegans
      ZC513.5
      Danio rerio
      alg12
      Drosophila melanogaster
      CG8412
      Homo sapiens
      ALG12
      Mus musculus
      Alg12
      Rattus norvegicus
      Alg12
      Schizosaccharomyces pombe
      alg12

      External links

      Saccharomyces Genome Database
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (855764)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar