Saccharomyces cerevisiaeGenAge entry for HRD1 (Saccharomyces cerevisiae)

Gene information (ID: 1313)

Symbol
HRD1
Aliases
DER3
Name
HMG-coA Reductase Degradation
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of hrd1, a target of the unfolded protein response signaling, increases replicative lifespan.
% change in avg or median lifespan
Mean lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mean chronological lifespan strongly decreased in the a strain
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Necessary for fitness
    Primary reference

      In other databases

      LongevityMap
      • A homolog of this gene for Homo sapiens is present as RNF145

      Homologs in other organisms

      Caenorhabditis elegans
      sel-11
      Caenorhabditis elegans
      Y119C1B.5
      Caenorhabditis elegans
      hrdl-1
      Danio rerio
      rnf145a
      Danio rerio
      amfr
      Danio rerio
      syvn1
      Danio rerio
      CR559945.1
      Danio rerio
      rnf139
      Danio rerio
      rnf145b
      Danio rerio
      amfrb
      Drosophila melanogaster
      Trc8
      Drosophila melanogaster
      sip3
      Homo sapiens
      AMFR
      Homo sapiens
      RNF145
      Homo sapiens
      RNF139
      Homo sapiens
      SYVN1
      Mus musculus
      Amfr
      Mus musculus
      Rnf139
      Mus musculus
      Syvn1
      Mus musculus
      Rnf145
      Rattus norvegicus
      Amfr
      Rattus norvegicus
      Rnf145
      Rattus norvegicus
      Rnf139
      Rattus norvegicus
      Syvn1
      Schizosaccharomyces pombe
      hrd1

      External links

      Saccharomyces Genome Database
      Search
      Ensembl
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      Entrez Gene
      View on Entrez Gene database (854149)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar