- Symbol
- HRD1
- Aliases
- DER3
- Name
- HMG-coA Reductase Degradation
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- Deletion of hrd1, a target of the unfolded protein response signaling, increases replicative lifespan.
- % change in avg or median lifespan
- Mean lifespan is 18% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Mean chronological lifespan strongly decreased in the a strain
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- LongevityMap
- A homolog of this gene for Homo sapiens is present as RNF145
- Caenorhabditis elegans
- sel-11
- Caenorhabditis elegans
- Y119C1B.5
- Caenorhabditis elegans
- hrdl-1
- Danio rerio
- rnf145a
- Danio rerio
- amfr
- Danio rerio
- syvn1
- Danio rerio
- CR559945.1
- Danio rerio
- rnf139
- Danio rerio
- rnf145b
- Danio rerio
- amfrb
- Drosophila melanogaster
- Trc8
- Drosophila melanogaster
- sip3
- Homo sapiens
- AMFR
- Homo sapiens
- RNF145
- Homo sapiens
- RNF139
- Homo sapiens
- SYVN1
- Mus musculus
- Amfr
- Mus musculus
- Rnf139
- Mus musculus
- Syvn1
- Mus musculus
- Rnf145
- Rattus norvegicus
- Amfr
- Rattus norvegicus
- Rnf145
- Rattus norvegicus
- Rnf139
- Rattus norvegicus
- Syvn1
- Schizosaccharomyces pombe
- hrd1
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (854149)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for HRD1 (Saccharomyces cerevisiae)