- Symbol
- utx-1
- Name
- Protein UTX-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- RNAi of the utx-1 gene extended the mean life span of worms, dependent on DAF-16 activity and not additive in daf-2 mutants. The loss of utx-1 increased H3K27me3 on the Igf1r/daf-2 gene and decreased IIS activity, resulting into an epigenetic state closer to that of younger worms.
- % change in avg or median lifespan
- Average lifespan is aproximately 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- RNA inteference of utx-1 results in an incrased lifespan of up to 19%, depending on temperature.
- % change in avg or median lifespan
- Mean lifespan is 19% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as KDM6B
- Danio rerio
- kdm6al
- Danio rerio
- kdm6a
- Danio rerio
- kdm6bb
- Danio rerio
- kdm6ba
- Drosophila melanogaster
- Utx
- Homo sapiens
- KDM6B
- Homo sapiens
- KDM6A
- Homo sapiens
- UTY
- Mus musculus
- Kdm6b
- Mus musculus
- Kdm6a
- Mus musculus
- Uty
- Rattus norvegicus
- Kdm6a
- Rattus norvegicus
- Kdm6b
- Saccharomyces cerevisiae
- CYC8
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (181110)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for utx-1 (Caenorhabditis elegans)