- Symbol
- daf-16
- Name
- Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Forkhead family transcription factor
- Observations
- The increased lifespan of daf-2 and daf-23 mutants is suppressed completely by a daf-16 mutation.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mutations in daf-16 suppress the life-extension caused by several mutations, including daf-2.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- 70% decrease in median lifespan in daf-2 background and 45% decrease in lifespan in wild-type background.
- % change in avg or median lifespan
- Average lifespan is 45% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as FOXO1
- A homolog of this gene for Homo sapiens is present as FOXO3
- A homolog of this gene for Homo sapiens is present as FOXO4
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Mus musculus is present as Foxo3
- This gene is present as daf-16
- LongevityMap
- A homolog of this gene for Homo sapiens is present as FOXO1
- A homolog of this gene for Homo sapiens is present as FOXO3
- A homolog of this gene for Homo sapiens is present as FOXO4
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXO3
- Danio rerio
- foxo4
- Danio rerio
- si:dkey-11f5.5
- Danio rerio
- si:ch211-206a7.2
- Danio rerio
- foxo1b
- Danio rerio
- foxo1a
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Homo sapiens
- FOXO3
- Homo sapiens
- FOXO1
- Homo sapiens
- FOXO4
- Homo sapiens
- FOXO6
- Mus musculus
- Foxo6
- Mus musculus
- Foxo4
- Mus musculus
- Foxo3
- Mus musculus
- Foxo1
- Rattus norvegicus
- Foxo4
- Rattus norvegicus
- Foxo3
- Rattus norvegicus
- Foxo1
- Rattus norvegicus
- Foxo6
- Saccharomyces cerevisiae
- HCM1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (172981)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for daf-16 (Caenorhabditis elegans)