- Symbol
- Coq7
- Aliases
- clk-1
- Name
- demethyl-Q 7
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Ubiquinone (coenzyme Q, CoQ) biosynthesis
- Observations
- Clk-1 deficient mice are embryonic lethal, however deficient mice transgenically expressing clk-1 (Tg96/I) live longer (on average 23% longer for males and 14% for females) and have smaller bodies than wild-type mice. The Tg96/I mice have CoQ levels equivalent to wild-type mice, exhibit reduced whole-body oxygen consumption during the dark period, and have lean leg skeletal muscles with reduced mitochondrial VO2 and ATP content compared with wild-type mice.
- % change in max lifespan
- Maximum lifespan is 20% higher in males and 12% higher in females.
- % change in avg or median lifespan
- Median lifespan is 23% higher in males and 14% higher in females.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Transgenic
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Heterozygous mice live about 15 to 30% longer than controls.
- % change in avg or median lifespan
- Lifespan is 15-30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as clk-1
- A homolog of this gene for Saccharomyces cerevisiae is present as CAT5
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as COQ7
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as clk-1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as COQ7
- Caenorhabditis elegans
- clk-1
- Danio rerio
- coq7
- Drosophila melanogaster
- COQ7
- Homo sapiens
- COQ7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (12850)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Coq7 (Mus musculus)