Mus musculusGenAge entry for Cav1 (Mus musculus)

Gene information (ID: 93)

Symbol
Cav1
Aliases
Cav; Cav-1
Name
caveolin, caveolae protein 1
Organism
Mus musculus (AnAge)
Known functions and activities
Component of caveolae membranes in nonmuscle cells

Potential relevance to longevity and/or ageing

Observations
Knockout mice are viable and fertile but exhibit an approximately 50% reduction in lifespan probably due to a combination of pulmonary fibrosis, pulmonary hypertension, and cardiac hypertrophy.
% change in avg or median lifespan
Lifespan is 50% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    CellAge
    • A homolog of this gene for Homo sapiens is present as CAV1

    Homologs in other organisms

    Danio rerio
    cav1
    Homo sapiens
    CAV1
    Rattus norvegicus
    Cav1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (12389)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
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