DrugAge entry for Vitamin E

Vitamin E 
(+)-alpha-Tocopherol • (+)-|A-Tocopherol • (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL • (2R,4'R,8'R)-alpha-Tocopherol • (R,R,R)-alpha-Tocopherol • 10191-41-0 • 5,7,8-Trimethyltocol • 59-02-9 • a-Tocopherol • a-Vitamin E • alpha-Tocopherol • alpha-Tocopherol, D- • Aquasol E • D-alpha tocopherol • D-alpha-Tocopherol • Denamone • dl-a-Tocopherol • DL-ALPHA-TOCOPHEROL • Eprolin • Mixed tocopherols • Phytogermine • Syntopherol • VITAMIN E • Vitamin Ea • Viteolin 
CAS Number
PubChem CID
SEP-L1000 side effects
Abdominal pain, Asthenia, Body temperature increased, Constipation, Convulsion, Cough, Diarrhoea, Dizziness, Dry mouth, Dyspepsia, Dyspnoea, Fatigue, Headache, Hyperhidrosis, Hypersensitivity, Hypotension, Insomnia, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Urticaria, Vision blurred, Vomiting 


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Vitamin E


Harrington, LA and Harley, CB (1988) Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech. Ageing Dev. 43(1)71-78 PubMed
Sawada, M and Enesco, HE (1984) Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli. Exp. Gerontol. 19(3)179-183 PubMed
Enesco, HE and Verdone-Smith, C (1980) alpha-Tocopherol increases lifespan in the rotifer Philodina. Exp. Gerontol. 15(5)335-338 PubMed
Miquel, J et al. (1982) Antioxidants, metabolic rate and aging in Drosophila. Arch Gerontol Geriatr 1(2)159-165 PubMed
Thomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Adachi, H and Ishii, N (2000) Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 55(6)B280-B285 PubMed
Ishii, N et al. (2004) Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech. Ageing Dev. 125(1)41-46 PubMed
Sawada, M et al. (1990) The effects of UV radiation and antioxidants on life span and lipid peroxidation in the rotifer Asplanchna brightwelli. Arch Gerontol Geriatr 10(1)27-36 PubMed
Zou, S et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech. Ageing Dev. 128(2)222-226 PubMed
Selman, C et al. (2008) Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuvenation Res 11(1)83-96 PubMed

DGIdb Human Drug-Gene Interactions for Vitamin E

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Vitamin E

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id