DrugAge entry for Paraquat

Name: Paraquat
Synonyms: 1,1'-Dimethyl-4,4'-bipyridinium • 1,1'-Dimethyl-4,4'-bipyridinium cation • 1,1'-Dimethyl-4,4'-bipyridinium salt • 1,1'-Dimethyl-4,4'-bipyridyldiylium • 4,4'-Bipyridinium, 1,1'-dimethyl- • 4685-14-7 • CCRIS 7731 • CHEBI:34905 • Dextrone X • Dimethyl viologen • EINECS 225-141-7 • HSDB 1668 • Methyl viologen (2+) • Methyl viologen ion(2+) • N,N'-Dimethyl-4,4'-bipyridinium • N,N'-Dimethyl-4,4'-bipyridinium dication • N,N'-Dimethyl-gamma,gamma'-dipyridylium • PARAQUAT • Paraquat dication • Paraquat ion • Paraquat [ANSI:BSI:ISO] • Spraytop-graze • Starfire • UNII-PLG39H7695 • Weedol
CAS Number: 4685-14-7
IUPAC Name: 1-methyl-4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium
PubChem CID: 15939

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Paraquat

Average/Median Lifespan
Max Lifespan
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References

Yang, W and Hekimi, S (2010) A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 8(12)e1000556 PubMed
Xiong LG et al. (2018) Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans () PubMed
Scialo F, et al. (2016) Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metabolism () PubMed
Abergel R, et al. (2017) Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell () PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed
R G Allen (1984) Effects of paraquat administration on longevity, oxygen consumption, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, inorganic peroxides and glutathione in the adult housefly Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 78(2)283-288 PubMed

DGIdb Human Drug-Gene Interactions for Paraquat

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Paraquat

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id