DrugAge entry for Paraquat

Name
Paraquat 
Synonyms
1,1'-Dimethyl-4,4'-bipyridinium • 1,1'-Dimethyl-4,4'-bipyridinium cation • 1,1'-Dimethyl-4,4'-bipyridinium salt • 1,1'-Dimethyl-4,4'-bipyridyldiylium • 4,4'-Bipyridinium, 1,1'-dimethyl- • 4685-14-7 • CCRIS 7731 • CHEBI:34905 • Dextrone X • Dimethyl viologen • EINECS 225-141-7 • HSDB 1668 • Methyl viologen (2+) • Methyl viologen ion(2+) • N,N'-Dimethyl-4,4'-bipyridinium • N,N'-Dimethyl-4,4'-bipyridinium dication • N,N'-Dimethyl-gamma,gamma'-dipyridylium • PARAQUAT • Paraquat dication • Paraquat ion • Paraquat [ANSI:BSI:ISO] • Spraytop-graze • Starfire • UNII-PLG39H7695 • Weedol 
CAS Number
4685-14-7 
IUPAC Name
1-methyl-4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium 
PubChem CID
15939 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Paraquat


References

Yang, W and Hekimi, S (2010) A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 8(12)e1000556 PubMed
Xiong LG et al. (2018) Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans () PubMed
Scialo F, et al. (2016) Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metabolism () PubMed
Abergel R, et al. (2017) Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell () PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed

DGIdb Human Drug-Gene Interactions for Paraquat

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Paraquat

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id