DrugAge entry for Nordihydroguaiaretic acid

Nordihydroguaiaretic acid 
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- • 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane • 2,3-Bis(3,4-dihydroxyphenylmethyl)butane • 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol) • 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol • 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol • 500-38-9 • beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane • Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- • CCRIS 1399 • CHEMBL52 • Dihydronorguaiaretic acid • Dinorguaiaretic acid, dihydro- • EINECS 207-903-0 • NDGA • NDGA, Larrea divaricata • NORDIHYDROGUAIARETIC ACID • Nordihydroguaiaretic acid (unspecified) • Nordihydroguairaretic acid • nordihydroguaretic acid • Norguaiaretic acid, dihydro- • Norhydroguaiaretic acid • NSC 4291 • NSC 682984 • Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di- 
CAS Number
PubChem CID


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Nordihydroguaiaretic acid


Richie, JP et al. (1986) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183(1)81-85 PubMed
Strong, R et al. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7(5)641-650 PubMed
Spindler, SR et al. (2015) Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. J. Gerontol. A Biol. Sci. Med. Sci. 70(12)1479-1489 PubMed

DGIdb Human Drug-Gene Interactions for Nordihydroguaiaretic acid

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Nordihydroguaiaretic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id