DrugAge entry for Nordihydroguaiaretic acid

Name
Nordihydroguaiaretic acid 
Synonyms
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- • 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane • 2,3-Bis(3,4-dihydroxyphenylmethyl)butane • 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol) • 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol • 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol • 500-38-9 • beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane • Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- • CCRIS 1399 • CHEMBL52 • Dihydronorguaiaretic acid • Dinorguaiaretic acid, dihydro- • EINECS 207-903-0 • NDGA • NDGA, Larrea divaricata • NORDIHYDROGUAIARETIC ACID • Nordihydroguaiaretic acid (unspecified) • Nordihydroguairaretic acid • nordihydroguaretic acid • Norguaiaretic acid, dihydro- • Norhydroguaiaretic acid • NSC 4291 • NSC 682984 • Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di- 
CAS Number
500-38-9 
IUPAC Name
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol 
PubChem CID
4534 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Nordihydroguaiaretic acid


References

Richie, JP et al. (1986) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183(1)81-85 PubMed
Strong, R et al. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7(5)641-650 PubMed
Spindler, SR et al. (2015) Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. J. Gerontol. A Biol. Sci. Med. Sci. 70(12)1479-1489 PubMed

DGIdb Human Drug-Gene Interactions for Nordihydroguaiaretic acid

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Nordihydroguaiaretic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id