DrugAge entry for Melatonin

Name
Melatonin 
Synonyms
5-Methoxy-N-acetyltryptamine • 73-31-4 • Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- • Circadin • Melapure • Melatol • Melatonex • Melatonin • Melatonina (TN) • Melatonine • Melovine • N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide • N-Acetyl-5-methoxytryptamine • N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide • N-[2-(5-methoxyindol-3-yl)ethyl]acetamide • Nature'S Harmony • Night Rest • Pineal Hormone • Posidorm • Revital Melatonin • Rx Balance • Sleep Right • UNII-JL5DK93RCL • Vivitas • [3H]melatonin 
CAS Number
73-31-4 
IUPAC Name
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide 
PubChem CID
896 
SEP-L1000 side effects
Abdominal pain, Anxiety, Asthenia, Body temperature increased, Confusional state, Constipation, Cough, Decreased appetite, Diarrhoea, Dizziness, Dry mouth, Dyspnoea, Erythema, Fatigue, Flushing, Hallucination, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Hypotension, Insomnia, Leukopenia, Malaise, Myalgia, Nausea, Nervous system disorder, Oedema, Pain, Paraesthesia, Pharyngitis, Pruritus, Rash, Rhinitis, Somnolence, Tachycardia, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Melatonin


References

Pierpaoli, W and Regelson, W (1994) Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. U.S.A. 91(2)787-791 PubMed
Thomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Izmaylov, DM and Obukhova, LK (1999) Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster. Mech. Ageing Dev. 106(3)233-240 PubMed
Anisimov, VN et al. (2001) Melatonin increases both life span and tumor incidence in female CBA mice. J. Gerontol. A Biol. Sci. Med. Sci. 56(7)B311-B323 PubMed
Bonilla, E et al. (2002) Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin. Exp. Gerontol. 37(5)629-638 PubMed

DGIdb Human Drug-Gene Interactions for Melatonin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Melatonin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id