DrugAge entry for Indirubin

Name
Indirubin 
Synonyms
(delta(sup 2,3')-BIINDOLINE)-2',3-DIONE • (E)-[2,3'-biindolinylidene]-2',3-dione • 397242-72-7 • 479-41-4 • 5-24-08-00507 (Beilstein Handbook Reference) • AC1NSDZI • AK128411 • BRN 0088279 • C.I. 73200 • C16H10N2O2 • Couroupitine B • CPD000466311 • EM-A05-INDIRUBIN • Indigo Red • Indigopurpurin • Indirubin • MLS000759416 • MLS001424211 • NSC 105327 • NSC-105327 • Q-100514 • SCHEMBL27678 • SMR000466311 • UNII-V86L8P74GI • [2,3'-Biindolinylidene]-2',3-dione 
CAS Number
479-41-4 
IUPAC Name
(3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one 
PubChem CID
5359405 
SEP-L1000 side effects
Abdominal pain, Anaemia, Body temperature increased, Constipation, Decreased appetite, Diarrhoea, Dizziness, Erythema, Headache, Hyperhidrosis, Hypersensitivity, Nausea, Neutropenia, Oedema, Pain, Pruritus, Rash, Somnolence, Thrombocytopenia, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Indirubin


References

Spindler, SR et al. (2012) Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. PLoS ONE 7(2)e29782 PubMed

DGIdb Human Drug-Gene Interactions for Indirubin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Indirubin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id