DrugAge entry for Epigallocatechin-3-gallate

Name
Epigallocatechin-3-gallate 
Synonyms
(-)-EGCG • (-)-epigallocatechin 3-gallate • (-)-Epigallocatechin gallate • (-)-Epigallocatechin-3-o-gallate • (-)-Epigallocatechol gallate • (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate • (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate • 989-51-5 • BQM438CTEL • C22H18O11 • Catechin deriv. • CCRIS 3729 • CHEBI:4806 • CHEMBL297453 • EGCG • Epigallocatechin 3-gallate • Epigallocatechin gallate • Epigallocatechin-3-gallate • Epigallocatechin-3-monogallate • Epigallocatechol, 3-gallate, (-)- • Green tea extract • Tea catechin • Teavigo • UNII-BQM438CTEL • WMBWREPUVVBILR-WIYYLYMNSA-N 
CAS Number
989-51-5 
IUPAC Name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate 
PubChem CID
65064 
SEP-L1000 side effects
Alopecia, Anxiety, Arthralgia, Asthenia, Body temperature increased, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Gastrointestinal disorder, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Hypotension, Infection, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Thrombocytopenia, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Epigallocatechin-3-gallate


References

Brown, MK et al. (2006) Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacol. Biochem. Behav. 85(3)620-628 PubMed
Abbas, S and Wink, M (2009) Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med. 75(3)216-221 PubMed
Bartholome, A et al. (2010) Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch. Biochem. Biophys. 501(1)58-64 PubMed
Niu, Y et al. (2013) The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats. Aging Cell 12(6)1041-1049 PubMed
Wagner, AE et al. (2015) Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster. Oncotarget 6(31)30568-30578 PubMed
Xiong LG et al. (2018) Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans () PubMed
Li, H et al. (2019) Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in Food Chem X 1()100005 PubMed
Rodrigo Dutra Nunes (2016) Polyphenol-Rich Diets Exacerbate AMPK-Mediated Autophagy, Decreasing Proliferation of Mosquito Midgut Microbiota, and Extending Vector Lifespan Plos Neglected Tropical Diseases 10(10)e0005034 PubMed

DGIdb Human Drug-Gene Interactions for Epigallocatechin-3-gallate

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Epigallocatechin-3-gallate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id