DrugAge entry for Curcumin

Name
Curcumin 
Synonyms
458-37-7 • C.I. Natural Yellow 3 • Curcuma • curcumin • Curcumin I • Diferuloylmethane • Gelbwurz • Golden seal • Haidr • Halad • Haldar • Halud • Indian saffron • Kacha haldi • Merita earth • Natural yellow 3 • Orange Root • Safran d'Inde • Souchet • Terra Merita • Turmeric • Turmeric yellow • Yellow Ginger • Yellow Root • Yo-Kin 
CAS Number
458-37-7 
IUPAC Name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione 
PubChem CID
969516 
SEP-L1000 side effects
Abdominal pain, Alopecia, Arrhythmia, Asthenia, Body temperature increased, Confusional state, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Erythema, Fatigue, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Infection, Insomnia, Malaise, Myalgia, Nausea, Neuropathy peripheral, Oedema, Pain, Paraesthesia, Pruritus, Rash, Tachycardia, Urticaria, Vertigo, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Curcumin


References

Lee, KS et al. (2010) Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res 13(5)561-570 PubMed
Liao, VH et al. (2011) Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech. Ageing Dev. 132(10)480-487 PubMed
Strong, R et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 68(1)6-16 PubMed
Shen, LR et al. (2013) Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Age (Dordr) 35(4)1133-1142 PubMed
Soh, JW et al. (2013) Curcumin is an early-acting stage-specific inducer of extended functional longevity in Drosophila. Exp. Gerontol. 48(2)229-239 PubMed
Suckow, BK and Suckow, MA (2006) Lifespan extension by the antioxidant curcumin in Drosophila melanogaster. Int J Biomed Sci 2(4)402-405 PubMed
Chandrashekara, KT et al. (2014) Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster. Age (Dordr) 36(5)9702 PubMed
Li, J et al. (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp. Gerontol. 67()62-71 PubMed
Arking, R. (2015) Independent chemical regulation of health and senescent spans in Drosophila. Invertebr. Reprod. Dev. 59(sup1)28-32 PubMed
Chen Y, et al. (2018) Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions Biofactors () PubMed

DGIdb Human Drug-Gene Interactions for Curcumin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Curcumin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id