DrugAge entry for Aspirin

Name
Aspirin 
Synonyms
2-(Acetyloxy)benzoic acid • 2-Acetoxybenzoic acid • 50-78-2 • Acenterine • Aceticyl • Acetonyl • Acetophen • Acetosal • Acetosalin • Acetylin • Acetylsalicylate • ACETYLSALICYLIC ACID • Acylpyrin • Aspergum • Aspirdrops • aspirin • Colfarit • Easprin • Ecotrin • Enterosarein • o-Acetoxybenzoic acid • O-Acetylsalicylic acid • o-Carboxyphenyl acetate • Polopiryna • Salicylic acid acetate 
CAS Number
50-78-2 
IUPAC Name
2-acetyloxybenzoic acid 
PubChem CID
2244 
SEP-L1000 side effects
Anaemia, Anaphylactic shock, Angioedema, Asthma, Confusional state, Diarrhoea, Dyspepsia, Haematemesis, Hearing impaired, Hyperhidrosis, Hypersensitivity, Leukopenia, Melaena, Nausea, Oedema, Pruritus, Purpura, Rash, Somnolence, Thirst, Thrombocytopenia, Tinnitus, Ulcer, Urticaria, Vertigo, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Aspirin


References

Strong, R et al. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7(5)641-650 PubMed
Ayyadevara, S et al. (2013) Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid. Redox Signal. 18(5)481-490 PubMed
Wan, QL et al. (2013) Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp. Gerontol. 48(5)499-506 PubMed
Hans, H et al. (2015) Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension? Age (Dordr) 37(2)31 PubMed
Huang XB, et al. (2017) Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One () PubMed

DGIdb Human Drug-Gene Interactions for Aspirin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Aspirin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id