DrugAge entry for Ascorbic acid

Ascorbic acid 
50-81-7 • Allercorb • Ascoltin • Ascorbajen • ascorbate • ascorbic acid • Ascorbicap • Ascorbutina • Ascorteal • Cescorbat • Cetemican • Cevitamic acid • Cevitamin • Citriscorb • Hybrin • L(+)-Ascorbic acid • L-ascorbate • l-ascorbic acid • Laroscorbine • Lemascorb • Natrascorb • Proscorbin • Roscorbic • Secorbate • vitamin C 
CAS Number
PubChem CID


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Ascorbic acid


Harrington, LA and Harley, CB (1988) Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech. Ageing Dev. 43(1)71-78 PubMed
Thomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed

DGIdb Human Drug-Gene Interactions for Ascorbic acid

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Ascorbic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id