DrugAge entry for Alpha-lipoic acid

Alpha-lipoic acid 
(RS)-Lipoic acid • 1,2-dithiolane-3-pentanoic acid • 1,2-Dithiolane-3-valeric acid • 1077-28-7 • 5-(1,2-Dithiolan-3-yl)pentanoic acid • 6,8-Dithiooctanoic acid • 6,8-Thioctic acid • 6-Thioctic acid • alpha Lipoic Acid • alpha-Lipoic acid • alpha-liponic acid • alpha-Liponsaeure • DL-6,8-Thioctic acid • DL-6-Thioctic acid • DL-alpha-Lipoic acid • dl-Lipoic acid • dl-Thioctic acid • Liposan • Lipothion • Rac-lipoate • Thioctacid • thioctic acid • Thioctic acid dl-form • Thioctsan • Tioctacid 
CAS Number
5-(dithiolan-3-yl)pentanoic acid 
PubChem CID


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Alpha-lipoic acid


Bauer, JH et al. (2004) An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 101(35)12980-12985 PubMed
Brown, MK et al. (2006) Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Pharmacol. Biochem. Behav. 85(3)620-628 PubMed
Merry, BJ et al. (2008) Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span. Mech. Ageing Dev. 129(6)341-348 PubMed
Benedetti, MG et al. (2008) Compounds that confer thermal stress resistance and extended lifespan. Exp. Gerontol. 43(10)882-891 PubMed

DGIdb Human Drug-Gene Interactions for Alpha-lipoic acid

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Alpha-lipoic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id