Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: eat-2

Gene Information (Entrez Gene ID: 175072)

Symbol
eat-2
Name
EATing: abnormal pharyngeal pumping
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
175072

Potential relevance to dietary restriction and ageing

Observations

eat-2 mutants have reduced neuronal signalling due to the loss of the eat-2 nicotinic acetylcholine receptor resulting in decreased pharyngeal pumping that induces a DR-like state by restricting feeding. They are considered a genetic model of DR and live significant longer by up to 57 % [1820]. Solid DR further increases the long lifespan of eat-2 mutants [2568].

References

    In other databases

    GenAge model organism genes
    • This gene is present as eat-2

    Homologs

    Danio rerio
    si:ch211-39a7.1
    Danio rerio
    si:ch73-380n15.2
    Danio rerio
    CABZ01069081.1
    Danio rerio
    chrna7
    Drosophila melanogaster
    nAChRalpha5
    Drosophila melanogaster
    nAChRalpha6
    Drosophila melanogaster
    nAChRalpha7
    Homo sapiens
    CHRFAM7A
    Homo sapiens
    CHRNA7
    Homo sapiens
    CHRNA7
    Mus musculus
    Chrna7
    Rattus norvegicus
    Chrna7

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 175072
    Homologues
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    UniProt
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    Internet
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