GenDR Dietary Restriction Gene Manipulation: eat-2
Gene Information (Entrez Gene ID: 175072)
- Symbol
- eat-2
- Name
- EATing: abnormal pharyngeal pumping
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 175072
Potential relevance to dietary restriction and ageing
- Observations
-
eat-2 mutants have reduced neuronal signalling due to the loss of the eat-2 nicotinic acetylcholine receptor resulting in decreased pharyngeal pumping that induces a DR-like state by restricting feeding. They are considered a genetic model of DR and live significant longer by up to 57 % [1820]. Solid DR further increases the long lifespan of eat-2 mutants [2568].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as eat-2
Homologs
- Danio rerio
- si:ch211-39a7.1
- Danio rerio
- si:ch73-380n15.2
- Danio rerio
- CABZ01069081.1
- Danio rerio
- chrna7
- Drosophila melanogaster
- nAChRalpha5
- Drosophila melanogaster
- nAChRalpha6
- Drosophila melanogaster
- nAChRalpha7
- Homo sapiens
- CHRFAM7A
- Homo sapiens
- CHRNA7
- Homo sapiens
- CHRNA7
- Mus musculus
- Chrna7
- Rattus norvegicus
- Chrna7
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 175072
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar