Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: atg-7

Gene Information (Entrez Gene ID: 178005)

Symbol
atg-7
Name
AuTophaGy (yeast Atg homolog) 7
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
178005

Potential relevance to dietary restriction and ageing

Observations

RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg-7 RNAi does not affect lifespan of wild-type, but cancels out the lifespan extension effect of eat-2 mutation, a genetic model of DR [2244].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Atg7
    • This gene is present as atg-7
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
    CellAge
    • A homolog of this gene for Homo sapiens is present as ATG7

    Homologs

    Danio rerio
    atg7
    Drosophila melanogaster
    Atg7
    Homo sapiens
    ATG7
    Mus musculus
    Atg7
    Rattus norvegicus
    Atg7
    Saccharomyces cerevisiae
    ATG7
    Schizosaccharomyces pombe
    atg7

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 178005
    Homologues
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    UniProt
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    Internet
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