Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: NPT1

Gene Information (Entrez Gene ID: 854384)

Symbol
NPT1
Name
Nicotinate PhosphoribosylTransferase 1
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
854384

Potential relevance to dietary restriction and ageing

Observations

Increased dosage of NPT1 increases SIR2-dependent silencing and extends replicative lifespan by up to 60%. 0.5% glucose restriction does not significantly further increase replicative lifespan of NPT1 overexpression [2335]. NPT1 deletion decreases replicative lifespan by 50% [2550] as well as chronological lifespan [2510]. Deletion of NPT1 shortens the lifespan in W303R. Replicative lifespan extension of cdc25-10 mutation (assumed to act as a genetic DR-mimetic) is cancelled out by NPT1 deletion [2260].

References

    In other databases

    GenAge model organism genes
    • This gene is present as NPT1

    Homologs

    Schizosaccharomyces pombe
    SPAC1486.06

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 854384
    Homologues
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    UniProt
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    Internet
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