GenDR Dietary Restriction Gene Manipulation: skn-1
Gene Information (Entrez Gene ID: 177343)
Potential relevance to dietary restriction and ageing
RNA interference or mutations in skn-1 prevent the life-extension effects of dietary restriction . skn-1 transgenes that overexpress a constitutive nuclear form of SKN-1 in the intestine extend the mean lifespan by 5-21% . skn-1 mutation does not alter lifespan under ad lib, but cancels out the lifespan extension effect of liquid DR or food variation at all. Ectopic expression of skn-1b in ASI neurons rescued liquid DR longevity defects of skn-1. Therefore, skn-1 might be regulated by nutritional stress . Intermittent fasting significantly extends lifespan of skn-1 mutants . Solid DR extends lifespan of a skn-1 loss-of-function mutant and wild-type to a similar extent .
In other databases
- GenAge model organism genes
- This gene is present as skn-1
No homologs found