GenDR Dietary Restriction Gene Manipulation: daf-2
Gene Information (Entrez Gene ID: 175410)
- Symbol
- daf-2
- Name
- abnormal DAuer Formation 2
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 175410
Potential relevance to dietary restriction and ageing
- Observations
-
daf-2 mutants live more than twice as long as controls. Its relation to DR is unclear. daf-2 mutation extends lifespan of wild-type and eat-2 mutants [1820]. Long lifespan of daf-2 insulin receptor mutation is further extended by solid DR [2564]. DR by bacterial dilution extends lifespan of daf-2 mutants [2360]. Intermittent fasting does not markedly extend lifespan of daf-2 mutants [2566]. Bacterial dilution DR increases lifespan by 65%. daf-2 mutation further increases lifespan under bacterial dilution DR by 40% [2569]. DR from eat-2 mutation has an additive effect on lifespan of daf-2(e1370) adults, but not on lifespan of daf-2(e1368) adults [2600].
- References
-
In other databases
- GenAge model organism genes
- GenAge human genes
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as InR
- LongevityMap
Homologs
- Danio rerio
- igf1rb
- Danio rerio
- igf1ra
- Danio rerio
- insrb
- Danio rerio
- insra
- Drosophila melanogaster
- InR
- Homo sapiens
- INSRR
- Homo sapiens
- IGF1R
- Homo sapiens
- INSR
- Mus musculus
- Insrr
- Mus musculus
- Igf1r
- Mus musculus
- Insr
- Rattus norvegicus
- Insr
- Rattus norvegicus
- Igf1r
- Rattus norvegicus
- Insrr
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 175410
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar