Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: daf-2

Gene Information (Entrez Gene ID: 175410)

Symbol
daf-2
Name
abnormal DAuer Formation 2
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
175410

Potential relevance to dietary restriction and ageing

Observations

daf-2 mutants live more than twice as long as controls. Its relation to DR is unclear. daf-2 mutation extends lifespan of wild-type and eat-2 mutants [1820]. Long lifespan of daf-2 insulin receptor mutation is further extended by solid DR [2564]. DR by bacterial dilution extends lifespan of daf-2 mutants [2360]. Intermittent fasting does not markedly extend lifespan of daf-2 mutants [2566]. Bacterial dilution DR increases lifespan by 65%. daf-2 mutation further increases lifespan under bacterial dilution DR by 40% [2569]. DR from eat-2 mutation has an additive effect on lifespan of daf-2(e1370) adults, but not on lifespan of daf-2(e1368) adults [2600].

References

    In other databases

    GenAge model organism genes
    • This gene is present as daf-2
    • A homolog of this gene for Mus musculus is present as Igf1r
    • A homolog of this gene for Drosophila melanogaster is present as InR
    • A homolog of this gene for Mus musculus is present as Insr
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IGF1R
    • A homolog of this gene for Homo sapiens is present as INSR
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as InR
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as IGF1R
    • A homolog of this gene for Homo sapiens is present as INSR

    Homologs

    Danio rerio
    igf1rb
    Danio rerio
    igf1ra
    Danio rerio
    insrb
    Danio rerio
    insra
    Drosophila melanogaster
    InR
    Homo sapiens
    INSRR
    Homo sapiens
    IGF1R
    Homo sapiens
    INSR
    Mus musculus
    Insrr
    Mus musculus
    Igf1r
    Mus musculus
    Insr
    Rattus norvegicus
    Insr
    Rattus norvegicus
    Igf1r
    Rattus norvegicus
    Insrr

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 175410
    Homologues
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    UniProt
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    Internet
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