Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Mdh2

Gene Information (Entrez Gene ID: 42185)

Symbol
Mdh2
Aliases
CG 7998 CG7998 Dmel\CG7998 l(3)psg7 Mdh MDH-2 mdh2 mMdh psg7
Name
Malate dehydrogenase 2
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
42185

Potential relevance to dietary restriction and ageing

Observations

Wild type flies and flies containing mutant Mdh2 (56% activity compared to the wild type) were subjected to dietary restriction. Both wild type and mutant flies showed a significant increase in lifespan under dietary restriction compared to normal conditions. However, flies with mutant Mdh2 had a significantly longer lifespan than the wild type, demonstrating that decreased Mdh2 activity enhances the effects of dietary restriction.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mdh-2
    • A homolog of this gene for Saccharomyces cerevisiae is present as MDH1
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as MDH1

    Homologs

    Caenorhabditis elegans
    mdh-2
    Danio rerio
    mdh2
    Homo sapiens
    MDH2
    Mus musculus
    Mdh2
    Rattus norvegicus
    Mdh2
    Saccharomyces cerevisiae
    MDH1

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    ID 42185
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar