GenDR Dietary Restriction Gene Manipulation: Men
Gene Information (Entrez Gene ID: 47173)
- Symbol
- Men
- Aliases
- anon-WO0118547.278 CG10120 Dmel\CG10120 MDH Mdh-NADP Me ME mem men MEN
- Name
- Malic enzyme
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 47173
Potential relevance to dietary restriction and ageing
- Observations
-
A mutation that decreased Men activity (52% of the wild type) in flies lowered lifespan. Flies with mutant Men didn't display an increase in lifespan when subjected to dietary restriction, whereas wild type flies demonstrated a significant increase in lifespan, thus indicating that Men activity is required for the lifespan extending effects of dietary restriction.
- References
-
In other databases
- GenAge model organism genes
- This gene is present as Men
- CellAge
Homologs
- Caenorhabditis elegans
- men-1
- Danio rerio
- me2
- Danio rerio
- CABZ01025780.1
- Danio rerio
- me1
- Danio rerio
- me3
- Homo sapiens
- ME2
- Homo sapiens
- ME1
- Homo sapiens
- ME3
- Mus musculus
- Me1
- Mus musculus
- Me3
- Mus musculus
- Me2
- Rattus norvegicus
- Me2
- Rattus norvegicus
- Me1
- Rattus norvegicus
- Me3
- Saccharomyces cerevisiae
- MAE1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 47173
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar