GenDR Dietary Restriction Gene Manipulation: fos-1
Gene Information (Entrez Gene ID: 178987)
- FOS (B-Zip transcription factor) homolog
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Post-developmental RNA interference of fos-1 reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while interference of fos-1 extends lifespan by only 36%. Moreover, contrastly, the lifespan of daf-2 mutants is unaffected by fos-1 RNA interference suggesting that fos-1 plays a role specifically in dietary restriction.
No homologs found